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Trifluoromethylation

#PhenN_2Naph was demonstrated to replace #Ruphen3 or #Rubpy3 in light-driven #trifluoromethylation on a wide range of unsaturated alkenes. In the absence of HCOOK base, #ATRAproduct was observed where CF3I adds across the double bond.

#dihydrophenazine_publication



Du, Y.; Pearson, R. M.; Lim, C.-H.; Sartor, S. M.; Ryan, M. D.; Yang, H.; Damrauer, N. H.; Miyake, G. M., Strongly Reducing, Visible-Light Organic Photoredox Catalysts as Sustainable Alternatives to Precious Metals. Chem. Eur. J. 2017, 23, 10962. Link


Papers related to trifluoromethylation:


Nagib, D. A.; MacMillan, D. W. C., Trifluoromethylation of Arenes and Heteroarenes by Means of Photoredox Catalysis. Nature 2011, 480, 224-228. Link


Iqbal, N.; Choi, S.; Ko, E.; Cho, E. J., Trifluoromethylation of heterocycles via visible light photoredox catalysis. Tetrahedron Lett. 2012, 53, 2005. Link

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